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Latest research

Every month we collate a selection of the latest clinically-relevant research to help you keep up to date with the most important developments in the field of prostate cancer.

Articles have been selected based on impact factor of the journal, relevance to UK clinical practice and general interest. You may be able to access the full text from your Trust's library service or via ATHENS registration. Information from PubMed explains other ways to access full text articles. 

Research round up from the clinic - top four articles from May 2014 cover:

  1. Data from the SEER program suggest that definitive local therapy improves survival in men with metastatic PrCA at diagnosis

  2. BMI is associated with larger index tumors and worse outcome after radical prostatectomy
  3. A European study looking at the association between diabetes mellitus and risk of prostate cancer

  4. A meta-analysis to determine whether antibiotics are beneficial in the management of prostatitis

See below for more articles of interest published online in in May 2014

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Active Surveillance

Active surveillance and surgery in localized prostate cancer.

Kwon O, Hong SK.

Minerva Urol E Nefrol Ital J Urol Nephrol. 2014 May; [Epub ahead of print]

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Behaviour/Psychology

Community-based recreational football: a novel approach to promote physical activity and quality of life in prostate cancer survivors.

Bruun DM, Bjerre E, Krustrup P, Brasso K, Johansen C, Rørth M, et al.

Int J Environ Res Public Health. 2014;11(6):5567–85.

Cognitive functioning in men receiving androgen deprivation therapy for prostate cancer: a systematic review and meta-analysis.

McGinty HL, Phillips KM, Jim HSL, Cessna JM, Asvat Y, Cases MG, et al.

Support Care Cancer. 2014 May; [Epub ahead of print]

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BPH/Prostatitis/PIN

Chronic lower urinary tract symptoms in young men without symptoms of chronic prostatitis: urodynamic analyses in 308 men aged 50 years or younger.

Jeong SJ, Yeon JS, Lee JK, Jeong JW, Lee BK, Park YH, et al.

Korean J Urol. 2014 May;55(5):341–8.

Antibiotics are not beneficial in the management of category III prostatitis: a meta analysis.

Zhu Y, Wang C, Pang X, Li F, Chen W, Tan W.

Urol J. 2014;11(2):1377–85.

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Diagnosis/Screening

Novel Tools for Prostate Cancer Prognosis, Diagnosis, and Follow-Up.

Dimakakos A, Armakolas A, Koutsilieris M.

BioMed Res Int. 2014;2014:890697.

A 17-gene Assay to Predict Prostate Cancer Aggressiveness in the Context of Gleason Grade Heterogeneity, Tumor Multifocality, and Biopsy Undersampling.

Klein EA, Cooperberg MR, Magi-Galluzzi C, Simko JP, Falzarano SM, Maddala T, et al.

Eur Urol. 2014 May; [Epub ahead of print]

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Erectile Dysfunction

Drug Prescription for Erectile Dysfunction Before and After Diagnosis of Localized Prostate Cancer.

Plym A, Folkvaljon Y, Garmo H, Holmberg L, Johansson E, Fransson P, et al.

J Sex Med. 2014 May; [Epub ahead of print]

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Ethnicity

Racial Disparities in Prostate Cancer-Specific Mortality in Men With Low-Risk Prostate Cancer.

Mahal BA, Aizer AA, Ziehr DR, Hyatt AS, Choueiri TK, Hu JC, et al

Clin Genitourin Cancer. 2014 May; [Epub ahead of print]

Racial disparities in an aging population: The relationship between age and race in the management of African American men with high-risk prostate cancer.

Mahal BA, Ziehr DR, Aizer AA, Hyatt AS, Lago-Hernandez C, Choueiri TK, et al.

J Geriatr Oncol. 2014 May; [Epub ahead of print]

Prediction of non-biochemical recurrence rate after radical prostatectomy in a Japanese cohort: development of a postoperative nomogram.

Okubo H, Ohori M, Ohno Y, Nakashima J, Inoue R, Nagao T, et al.

Int J Urol. 2014 May;21(5):479–83.

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Imaging

Prospective evaluation of MRI-guided in-bore prostate biopsy versus systematic transrectal ultrasound (TRUS)-guided prostate biopsy in biopsy-naïve men with elevated prostate-specific antigen (PSA) levels.

Quentin M, Blondin D, Arsov C, Schimmöller L, Hiester A, Godehardt E, et al.

J Urol. 2014 May; [Epub ahead of print]

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Prostatectomy

Matched comparison of robot-assisted, laparoscopic and open radical prostatectomy regarding pathologic and oncologic outcomes in obese patients.

Busch J, Gonzalgo ML, Leva N, Ferrari M, Cash H, Kempkensteffen C, et al.

World J Urol. 2014 May; [Epub ahead of print]

BMI is associated with larger index tumors and worse outcome after radical prostatectomy.

Hayashi N, Matsushima M, Kido M, Naruoka T, Furuta A, Furuta N, et al.

Prostate Cancer Prostatic Dis. 2014 May; [Epub ahead of print]

Low detectable PSA after radical prostatectomy: treat or watch?

Koulikov D, Mohler MC, Mehedint DC, Attwood K, Wilding GE, Mohler JL

J Urol. 2014 May; [Epub ahead of print]

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Quality of Life

Long-term quality of life outcomes in patients with locally advanced prostate cancer after intensity-modulated radiotherapy combined with androgen deprivation.

Luo H, Cheng L, Cheng H, Fu Z, Liao S, Li D, et al

Med Oncol Northwood Lond Engl. 2014 Jun;31(6):991.

Health-related quality of life and psychological well-being in patients with benign prostatic hyperplasia.

Pinto JDO, He H-G, Chan SWC, Toh PC, Esuvaranathan K, Wang W.

J Clin Nurs. 2014 May; [Epub ahead of print]

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Risk Factors

Diabetes mellitus and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition.

Tsilidis KK, Allen NE, Appleby PN, Rohrmann S, Nöthlings U, Arriola L, et al.

Int J Cancer. 2014 May; [Epub ahead of print]

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Survival

Prognosis of prostate cancer with other primary malignancies.

Lim JH, You D, Jeong IG, Hong JH, Ahn H, Kim C-S.

Korean J Urol. 2014 May;55(5):327–34.

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Treatment

Prognostic impact of definitive local therapy of the primary tumor in men with metastatic prostate cancer at diagnosis: A population-based, propensity score analysis.

Antwi S, Everson TM

Cancer Epidemiol. 2014 May; [Epub ahead of print]

A Competing Risk Analysis of Cancer-Specific Mortality of Initial Treatment with Radical Prostatectomy versus Radiation Therapy in Clinically Localized High-Risk Prostate Cancer.

Lee JY, Cho KS, Kwon JK, Jeh SU, Kang HW, Diaz RR, et al.

Ann Surg Oncol. 2014 May; [Epub ahead of print]

Management of localized prostate cancer: the pendulum swings (back to the middle).

Vuong W, Sartor O, Pal SK.

Asian J Androl. 2014 May; [Epub ahead of print]