What we're funding now

Since 1996 we have invested over £23 million in prostate cancer research.

In February 2014 we funded over £2.3 million of pilot awards and project grants under our new 2012-2020 research strategy. See our latest awards here.

 

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All research

Institution
University of Dundee
Project title
Advanced magnetic resonance imaging (MRI) for prostate cancer diagnosis
Researcher
Mr Ghulam Nabi
Grant award
£499,936
Duration
2014 - 2019
Institution
Keele University
Project title
GAS5, a key regulator of advanced prostate cancer development and drug-resistance
Researcher
Professor Gwyn Williams
Grant award
£49,839
Duration
2014 - 2015
Institution
King's College London
Project title
Does the absence of a protein, known as DARC, increase prostate cancer severity in African-Caribbean men?
Researcher
Dr Christine Galustian
Grant award
£49,787
Duration
2014 - 2015
Institution
Imperial College London
Project title
Finding metabolic target genes in prostate cancer
Researcher
Dr Hector Keun
Grant award
£49,995
Duration
2014 - 2015
Institution
Queens University Belfast
Project title
Understanding how to improve the lives of men living with prostate cancer
Researcher
Dr Anna Gavin
Grant award
£101,148
Duration
2014 - 2015
Institution
Institute of Cancer Research
Project title
Alterations in a man's genetic make-up which lead to aggressive prostate cancer
Researcher
Professor Rosalind Eeles and Dr Zsofia Kote-Jarai
Grant award
£205,703
Duration
2014 - 2017
Institution
University of York
Project title
Can suppression of a stem cell control gene stop prostate cancer spreading?
Researcher
Professor Norman Maitland
Grant award
£192,658
Duration
2014 - 2017
Institution
Institute of Cancer Research
Project title
Identification of genetic changes that drive aggressive prostate cancer progression
Researcher
Dr Amanda Swain
Grant award
£220,818
Duration
2014 - 2017
Institution
Queen's University Belfast
Project title
Development of Legumain based therapeutic for the treatment of advanced prostate cancer
Researcher
Dr Rich Williams
Grant award
£384,126
Duration
2014 - 2017
Institution
University College London
Project title
Developing imaging methods to better assess the spread of prostate cancer to other body sites
Researcher
Dr Shonit Punwani
Grant award
£334,254
Duration
2014 - 2017
Institution
Queen Mary University of London
Project title
Search for a new way to identify and treat advanced prostate cancer
Researcher
Dr Tania Maffucci
Grant award
£213,740
Duration
2014 - 2017
Institution
Imperial College London
Project title
Predicting and reducing side-effects in prostate cancer therapy
Researcher
Dr Charlotte Bevan
Grant award
211,800.00
Duration
2014 - 2017
Institution
Institute of Cancer Research
Project title
Precision Medicine for a Subtype of Prostate Cancer associated with loss of the gene CHD1.
Researcher
Professor Johann de Bono
Grant award
£393,414
Duration
2014 - 2017
Institution
University of East Anglia
Project title
Nanomedicine for prostate cancer
Researcher
Dr Wafa Al-Jamal
Grant award
£749, 218
Duration
2014 - 2019
Institution
Newcastle University
Project title
Characterisation of KMT5A, a potential therapeutic target to treat advanced prostate cancer.
Researcher
Dr Kelly Coffey
Grant award
£688,207
Duration
2014 - 2019
Institution
Newcastle University
Project title
Characterising prostate cancer cells in blood
Researcher
Miss Alice Hartley
Grant award
£53,040
Duration
2013 - 2014
Institution
King's College London
Project title
Using the body’s immune system to fight prostate cancer
Researcher
Dr Deborah Enting
Grant award
£240,177
Duration
2013 - 2016
Institution
University of York
Project title
A novel approach to stop tumour growth
Researcher
Dr Mark Coles
Grant award
£99,136
Duration
2013 - 2016
Institution
Institute of Cancer Therapeutics, University of Bradford
Project title
Aldehyde dehydrogenases in prostate cancer
Researcher
Dr Klaus Pors
Grant award
£99,325
Duration
2013 - 2016
Institution
Imperial College London
Project title
Development of a novel strategy for targeting treatment refractory prostate cancer
Researcher
Dr Charlotte Bevan
Grant award
£99,155
Duration
2013 - 2016
Institution
Queen Mary University of London
Project title
A novel strategy to improve prostate cancer treatment by using a killing virus and drugs
Researcher
Dr Gunnel Hallden
Grant award
£99,996
Duration
2013 - 2016
Institution
Newcastle University, Newcastle
Project title
Understanding key regulator molecules important to the progression of advanced prostate cancer
Researcher
Professor Craig Robson
Grant award
£100,330
Duration
2013 - 2016
Institution
King's College London
Project title
Insight into the mechanisms linking the metabolism of fat to prostate cancer progression
Researcher
Dr Claire Wells and Dr. Mieke Van Hemelrijck
Grant award
£99,710
Duration
2013 - 2016
Institution
Queen's University, Belfast
Project title
A New DNA Vaccine for Prostate Cancer
Researcher
Dr Helen McCarthy
Grant award
£97,970
Duration
2013 - 2016
Institution
Paul Strickland Scanner Centre (Mount Vernon Hospital)
Project title
A new method to identify men suitable for treatment of recurrent prostate cancer
Researcher
Mr James Stirling
Summary
This project will fund a radiographer for four years to develop an analysis technique to identify men with recurrent prostate cancer who would be suitable candidates for additional curative therapy. The researcher will achieve this by using existing, advanced technologies to image the prostate glands of men with localised, recurrent prostate cancer, and combining the data in a new method of data analysis. This will help precisely identify the location, and extent, of recurrent cancer within the prostate. We hope that this will not only identify suitable men for existing curative therapy, but also pave the way for development of localised, curative treatments.
Grant award
£188,614.00
Duration
2013 - 2017
Institution
Institute of Cancer Research, Sutton
Project title
The development of genetic tests that can be performed on blood to allow the differentiation of aggressive from low activity prostate cancer and the identification of changes that cause resistance in patients receiving treatment
Researcher
Dr Gerhardt Attard
Grant award
£245,867.09
Duration
2013 - 2016
Institution
University of Dundee
Project title
Ultrasound characterisation of tissues' stiffness in prostate cancer
Researcher
Mr Ghulam Nabi
Grant award
£237,199
Duration
2013 - 2016
Institution
Newcastle University
Project title
How androgens drive prostate cancer cell growth
Researcher
Professor David Elliott
Grant award
£159,129
Duration
2013 - 2016
Institution
Srathclyde Institute for Pharmacy and Biological Sciences, Glasgow
Project title
Development of a new drug to treat advanced state prostate cancer
Researcher
Professor Simon Mackay
Grant award
£249,289
Duration
2013 - 2016
Institution
Newcastle University
Project title
Investigating mechanisms of hormone resistance in advanced prostate cancer using new models based on stem cell culture
Researcher
Professor Craig Robson
Grant award
£209,648
Duration
2013 - 2016
Institution
Queen Mary University of London
Project title
Identification of new drugs for prostate cancer
Researcher
Professor Marco Falasca
Grant award
£178,587
Duration
2013 - 2016
Institution
Cardiff University
Project title
Exploring new molecular and cellular pathways to better define risk in prostate cancer.
Researcher
Professor Alan Clarke
Grant award
£244,086
Duration
2013 - 2016
Institution
University of East Anglia
Project title
Creating new targeted combination therapies for patients with prostate cancer that has spread outside the prostate (metastatic)
Researcher
Professor Colin Cooper
Grant award
£250,000
Duration
2013 - 2016
Institution
University of Glasgow
Project title
Improving radiation treatment of prostate cancer
Researcher
Dr Rob Mairs
Grant award
£204,590.05
Duration
2013 - 2016
Institution
University of Southampton
Project title
Can we develop a new hormonally targeted treatment for prostate cancer?
Researcher
Dr Simon Crabb
Grant award
£112,802
Duration
2013 - 2015
Institution
University of Ulster
Project title
A new drug combination for treatment of advanced prostate cancer.
Researcher
Dr Jenny Worthington
Grant award
£213,603
Duration
2013 - 2016
Institution
University of York
Project title
Targeting the cells that initiate and maintain tumours with new therapies
Researcher
Dr Anne Collins
Grant award
£187.426
Duration
2013 - 2016
Institution
Barts Cancer Institute
Project title
Development of new blood based markers to measure drug effectiveness and to personalise treatment in prostate cancer patients.
Researcher
Dr Marco Gerlinger
Grant award
£50,000
Duration
2013 - 2014
Institution
University of Sheffield
Project title
RAMP-3 - a new target to prevent cancer spreading
Researcher
Professor Tim Skerry
Grant award
£49,978
Duration
2013 - 2013
Institution
King's College London
Project title
FAB4-guided P4 immune therapy for prostate cancer
Researcher
Dr Sophie Papa
Grant award
£50,000
Duration
2013 - 2014
Institution
St Thomas' Hospital, London
Project title
A new method to detect bone cancers that have spread from the prostate (metastases) and monitor their response to treatment
Researcher
Professor Gary Cook
Grant award
£49,900
Duration
2013 - 2015
Institution
King's College London
Project title
Developing a new localised immunotherapy for advanced prostate cancer
Researcher
Dr Christine Galustian
Grant award
£49,932
Duration
2013 - 2014
Institution
University of Bath
Project title
A new approach to delivery of super potent drugs to prostate tumours
Researcher
Professor Mike Threadgill
Summary
This project is to develop an advanced drug delivery system which will transport a highly toxic chemical in an inactive form through the body directly to the prostate tumour, whereby the chemical will become active and kill the prostate cancer cells. The system will not be toxic to other cells as the drug will only become active when it is triggered by the close proximity of prostate cancer cells.
Grant award
£101,992
Duration
2009 - 2012
Institution
Barts and the London School of Medicine
Project title
The public face of prostate cancer in the UK
Researcher
Professor Clive Seale
Summary
This is a study of the public image of prostate cancer in the media, and how it is reflected in policy documents issued by the government, the NHS and leading prostate cancer organisations. The impact of this public image on men’s experience of prostate cancer will be studied with a focus on ethnic differences. The study will also assess the strategies pursued by organisations campaigning to raise awareness of prostate cancer over the past 20 years.
Grant award
£66,295
Duration
2009 - 2012
Institution
Imperial College London
Project title
How does the enzyme SK1 help prostate cancer spread to other parts of the body?
Researcher
Dr Dmitry Pshezhetskiy and Dr Justin Sturge
Summary
The protein SK1 is more abundant in prostate cancer cells than in normal prostate cells, and this protein allows the cells to grow and move faster, thus allowing the cancer to spread (metastasise). Dr Pshezhetskiy and his team are investigating how SK1 might help prostate cancer cells to move outside the prostate and which drugs are the best ones to use to stop prostate cancer spreading to the bone.
Grant award
£123,632
Duration
2009 - 2012
Institution
Institute of Cancer Research and Royal Marsden Hospital
Project title
Examination of biomarkers in prostate biopsies from patients in two radiotherapy trials
Researcher
Dr Chris Parker
Summary
This project aims to identify differences in prostate cancer biopsies which will help predict how well radiotherapy will work and also predict the extent of side effects in different prostate tissue types. This will allow doctors to decide how much radiotherapy to use, based on its predicted level of success and the predicted amount of side effects.
Grant award
£126,801
Duration
2009 - 2011
Institution
University of Cambridge
Project title
Screening for novel factors in the prostate cancer response to hormones
Researcher
Professor David Neal
Summary
Hormone therapy for advanced cancer often has a limited period of efficacy due to the cancer becoming drug resistant. The androgen receptor (AR) is a key factor in the development of drug resistance, and this project aims to better understand how AR works and how the cancer develops resistance to hormone therapy treatment.
Grant award
£26,000
Duration
2009 - 2010
Institution
University of Ulster
Project title
Understanding prostate cancer response to the hormone therapy bicalutamide
Researcher
Professor Stephanie McKeown
Summary
Advanced prostate cancer is usually treated with hormone therapy, but often the cancer will develop resistance to the drugs and find new ways to continue growing. This project will test other drugs in combination with the hormone therapy bicalutamide to try and control advanced prostate cancer, thus preventing the cancer cells using other pathways to continue to grow.
Grant award
£96,401
Duration
2009 - 2012
Institution
Queen's University Belfast
Project title
Understanding the role of bacteria in prostate cancer
Researcher
Dr Andrew MacDowell
Summary
This study aims to detect the bacterium involved in causing acne, known as P.acnes, in the prostate and establish whether long term infection of the prostate with this bacterium may be responsible for triggering cancerous growth.
Grant award
£157,943
Duration
2009 - 2012
Institution
University of Southampton
Project title
A trial of devices designed to prevent or contain persistent urinary leakage following prostate cancer
Researcher
Dr Mandy Fader
Summary
A clinical trial of devices for managing urinary incontinence (leakage from the bladder) when used by men who have persistent leakage after prostate surgery for cancer.
Grant award
£106,517
Duration
2009 - 2011
Institution
Institute of Cancer Research and Royal Marsden Hospital
Project title
Finding out why the new drug Abiraterone, developed to treat men with advanced prostate cancer, eventually stops working
Researcher
Dr Johann de Bono
Summary
A translational laboratory-based study to determine the reasons for abiraterone stopping working and try to reverse this process; also to examine how this information can be used to deliver ‘personalised’ treatments to patients based on the way they respond to drugs.
Grant award
£248,028
Duration
2009 - 2012
Institution
University of Ulster
Project title
A novel role of vitamin D in protecting against prostate cancer
Researcher
Dr Paul Thompson
Summary
A translational laboratory-based study to determine whether vitamin D can suppress the generation of testosterone within prostate tumours and may have a role in preventing the progression of advanced prostate cancer.
Grant award
£164,754
Duration
2010 - 2013
Institution
University of Newcastle
Project title
Understanding the mechanisms involved in the development of hormone resistant prostate cancer
Researcher
Professor Craig Robson
Summary
A laboratory study of the androgen receptor protein - a key driver of prostate cancer growth - looking at whether the switch that turns this protein on and off becomes defective when prostate cancer becomes resistant to hormone therapy.
Grant award
£195,485
Duration
2010 - 2013
Institution
University of Leeds
Project title
Pre-clinical models of prostate cancer
Researcher
Professor Terence Rabbitts
Summary
A laboratory-based project to make a mouse model of prostate cancer for future drug testing that replicates the human disease more faithfully than existing models.
Grant award
£245.761
Duration
2010 - 2013
Institution
University of Belfast
Project title
A gene therapy treatment for advanced prostate cancer
Researcher
Dr Helen McCarthy
Summary
A laboratory study of a new gene therapy system to determine whether it might be able to safely and effectively deliver a toxic gene to advanced prostate tumours around the body while sparing healthy tissue.
Grant award
£95,314
Duration
2010 - 2013
Institution
University of Oxford
Project title
Exploiting defects in prostate cancer for new therapies
Researcher
Dr Freddie Hamdy
Summary
A laboratory study of DNA repair in advanced prostate cancer cells, to identify whether defects in a pathway known as "homologous recombination" might provide potential new drug targets.
Grant award
£248,975
Duration
2010 - 2013
Institution
University of Belfast
Project title
Living with and beyond Prostate Cancer: Does more investigation result in better health? A study of the impact on men of increased and variable investigation and treatment of prostate cancer in the island of Ireland.
Researcher
Dr Anna Gavin
Summary
A wide-ranging clinical and psychosocial research project studying how the different approaches taken towards prostate cancer investigation and treatment in Northern Ireland and the Republic of Ireland have an overall impact on men's health.
Grant award
£299,648
Duration
2010 - 2013
Institution
Institute of Cancer Research
Project title
Can examining markers in the urine distinguish aggressive from non-aggressive prostate cancers?
Researcher
Professor Colin Cooper
Summary
A short pilot study, designed to form the basis of a larger clinical trial in future, testing how molecules in urine samples can be measured to help identify aggressive prostate tumours.
Grant award
£47,860
Duration
2010 - 2011
Institution
University of Bristol
Project title
Stopping prostate cancer growing and spreading by targeting blood vessels
Researcher
Professor David Bates
Summary
A basic laboratory study of the molecules controlling blood vessel growth within tumours aimed at finding out whether drugs could be developed to cut off the blood supply to prostate tumours, thereby starving cancer cells of nutrients and oxygen.
Grant award
£98,889
Duration
2010 - 2013
Institution
University College London
Project title
The use of breathing high oxygen-content gas to improve the outcome of prostate radiotherapy
Researcher
Dr Roberto Alonzi
Summary
The use of breathing high oxygen-content gas to improve the outcome of prostate radiotherapy. A small clinical trial testing whether the outcomes of radiotherapy for localised prostate cancer can be improved by using carbogen gas and nicotinamide (vitamin B3) to increase oxygen levels within the tumour.
Grant award
£243,712
Duration
2010 - 2013
Institution
Academic Unit of Pathology, Sheffield
Project title
Gene therapy for advanced prostate cancer
Researcher
Dr Munitta Muthana
Summary
This project is to investigate gene therapy of prostate cancer that has spread to the bone (metastasised) and developed into advanced cancer. The gene therapy is exploiting a type of blood cell called a macrophage, these blood cells are known to accumulate nearby to tumours. Using these macrophage blood cells to deliver drugs could allow direct targeting of the cancer cells with treatments, thus avoiding damaging any healthy tissue.
Grant award
£210,564
Duration
2007 - 2010
Institution
Institute of Cancer Research, Sutton
Project title
Identifying biomarkers that will help predict how individuals might be affected by their prostate cancer : A biopsy TMA analysis of biomarkers of prostate cancer behaviour
Researcher
Dr Chris Parker
Summary
This project will study multiple tumour tissue types to try and determine specific molecules as 'biomarkers' to identify which tumours are more aggressive and require radical treatment, from tumours which are less aggressive.
Grant award
£158,635
Duration
2007 - 2010
Institution
Department of Oncology, Imperial College London Hammersmith Campus
Project title
Researching a molecule that might make prostate cancer cells more susceptible to both chemotherapy and radiotherapy: mTor inhibition to sensitising prostate cancer to irradiation and docetaxel chemotherapy.
Researcher
Dr Dmitry Pshezhetskiy
Grant award
£118,893
Duration
2007 - 2010
Institution
Imperial College, Department of Oncology, Hammersmith Campus
Project title
Investigation of a new target for the prevention of prostate cancer spreading to bone : The role of Endo180 in prostate cancer cell migration and metastasis
Researcher
Dr Justin Sturge
Grant award
£97,093
Duration
2007 - 2010
Institution
Beatson Centre, Glasgow University
Project title
Developing a possible drug treatment for aggressive prostate cancer.
Researcher
Professor Hing Leung
Grant award
£73,690
Duration
2007 - 2009
Institution
Imperial College, London
Project title
Researching a gene that might be important in the early identification of aggressive prostate cancer, and also in creating a long lasting treatment for it
Researcher
Professor Mustafa Djamgoz
Grant award
£51,574
Duration
2007 - 2008
Institution
The University of Leicester
Project title
Research the support and information needs of carers for men with prostate cancer
Researcher
Paul Sinfield
Grant award
£83,564
Duration
2007 - 2008
Institution
Imperial College, London
Project title
Targeting of histone deacetylation to androgen regulated genes for therapeutic approaches in prostate cancer
Researcher
Dr Simak Ali and Dr Laki Buluwela
Summary
This study yielded new information regarding the gene expression changes brought about by the androgen receptor in prostate cancer cells.
Grant award
£186,279
Duration
2004 - 2007
Institution
Imperial College, London
Project title
Development of recombinant single chain Fv antibodies to human prostate cells for prostate research and therapy
Researcher
Dr Tahereh Kamalati
Summary
This project aimed to generate novel “tools” for better “detection” and “treatment” of prostate cancer cells in patients as well as “tools” for studying how prostate cancer develops. Such “tools”, currently do not exist but would be invaluable in prostate cancer therapy. In this context, this project successfully developed two unique human antibodies that can recognise prostate cancer cells and target them directly.
Grant award
£201,379
Duration
2004 - 2006
Institution
Imperial College, London
Project title
Investigation of Wnt function in the normal prostate and in prostate cancer. Investigation of sFRP-1 and Wnt11 function in prostate cancer. Beta-catenin localisation and function in prostate cancer cells
Researcher
Dr Robert Kypta
Summary
The results of this project indicated that the gene Wnt-11 is present at high levels in a significant number of patient tumours. 'Switching off' the Wnt-11 gene in cells from such tumours makes them less likely to survive hormone treatments and reduces the ability or more aggressive prostate cancer cells to spread. Thus, a therapy that targets Wnt-11 has the potential to kill prostate cancer cells and stop the more resistant cells from spreading. Since Wnt-11 is a protein that is found on the surface of prostate cancer cells this can be targeted using antibodies. There are presently no such antibodies available and a priority for the future is to make antibodies that will block Wnt-11 activity.
Grant award
£622,734
Duration
2004 - 2008
Institution
Imperial College, London
Project title
Downstream targets of androgen signalling: a proteomic approach
Researcher
Dr Charlotte Bevan
Summary
Treatment options for men who have relapsed on hormone therapy are very limited. Ultimately the outcomes of this work will include changes in androgen (hormone) receptor signalling to be used as a biomarker. This may allow for personalised therapy for advanced cancer, and the development of treatment options for men with advanced prostate cancer who have relapsed on current therapies.
Grant award
£543,424
Duration
2004 - 2007
Institution
Oxford Brookes University
Project title
A pilot study of a nurse-led intervention in primary care providing tailored advice and support to prostate cancer survivors on emotional and physical issues
Researcher
Professor Eila Watson
Summary
This project is a pilot trial to test the effectiveness of a nurse-led intervention which will target men with prostate-related problems (physical (eg urinary, bowel, sexual functioning) or psychological/ psychosexual) when they are 12-24 months post-diagnosis, and will offer individualised advice, support and follow-up. This trial is an essential first step required to generate the information needed to design and run a definitive, future trial to test its clinical and cost-effectiveness.
Grant award
£205,444
Duration
2012 - 2015
Institution
King's College London
Project title
Helping men to manage hot flushes and night sweats following prostate cancer treatments
Researcher
Professor Myra Hunter
Summary
This is a study to test if a self-management treatment (guided 4 week Self-Help with a booklet and a CD), that has been found to help women with similar symptoms, can reduce hot flushes and night sweats in men with prostate cancer.
Grant award
£261,001
Duration
2011 - 2013
Institution
Edinburgh Cancer Research Centre, Western General Hospital
Project title
The use of nitric oxide in combination with radiotherapy as a new treatment for prostate cancer
Researcher
Professor Fouad Habib
Grant award
£108,204
Duration
2008 - 2010
Institution
University of Aberdeen
Project title
New drug targets for the treatment of advanced prostate cancer
Researcher
Professor Iain McEwan
Summary
This project aims to identify new targets to develop treatments for drug-resistant, advanced prostate cancer.
Grant award
£81,634
Duration
2011 - 2014
Institution
Queen’s University Belfast
Project title
Improving radiotherapy treatment of prostate cancer
Researcher
Professor Kevin Prise
Summary
This study aims to improve the effects of radiotherapy treatment of prostate cancer by first investigating the causes of tumour resistance to radiotherapy. The next step is to use drugs which will prevent the tumour’s repair and recovery mechanisms from radiation exposure alongside radiotherapy treatment, to try and improve the efficacy of the treatment.
Grant award
£99,273
Duration
2011 - 2014
Institution
Queen's Institute for Medical Research, University of Edinburgh
Project title
Finding out how non-tumour cells control prostate cancer growth
Researcher
Dr Axel Thomson
Grant award
£145,738
Duration
2008 - 2011
Institution
University of Bath
Project title
Targeting a protein to treat prostate cancer that is no longer responding to hormone therapy
Researcher
Dr Matthew David Lloyd
Summary
The project is to study an important protein in prostate cancer, known as AMACR. The aim is to establish the role of AMACR protein in prostate cancer, and start the development of new medical treatments based on this knowledge.
Grant award
£91,110
Duration
2011 - 2014
Institution
University of Aberystwyth
Project title
Improved initial diagnosis and localisation of prostate cancer
Researcher
Professor Reyer Zwiggelaar
Summary
This project will investigate if the combination of magnetic resonance (MRI) and ultrasound information can provide improved initial diagnosis and localisation of prostate cancer. The study aims to improve diagnosis of prostate cancer, and also aims to improve staging and prognosis of the disease to assist treatment decision-making.
Grant award
£60,010
Duration
2011 - 2014
Institution
University College London
Project title
Improving needle biopsy for men affected by prostate cancer
Researcher
Dr Dean Barratt
Summary
This project proposal is to develop a new improved approach to guiding needle biopsy that will allow tissue samples to be collected with much higher accuracy than can be achieved using existing techniques.
Grant award
£74,014
Duration
2011 - 2013
Institution
Institute of Cancer Research, Sutton
Project title
A new approach to testing markers of prostate cancer
Researcher
Professor Colin Cooper
Summary
This project is a clinical study to test several highly promising new markers for prostate cancer in the blood and urine samples from 714 men undergoing a special type of prostate biopsy, called template mapping biopsy.
Grant award
£199,725
Duration
2012 - 2015
Institution
Imperial College London
Project title
Towards a novel therapy for prostate cancer
Researcher
Dr Charlotte Bevan
Summary
This study proposes to develop small molecules to increase levels of a protein called prohibitin in prostate tumours with the aim of stopping tumour growth. This is a promising new treatment strategy for prostate cancer.
Grant award
£243,893
Duration
2011 - 2014
Institution
University of Glasgow
Project title
What changes occur to make men with prostate cancer stop responding to therapy?
Researcher
Dr Joanne Edwards
Summary
This project aims to further our understanding of why prostate cancer therapy fails and identify novel proteins within prostate cancer cells that future drugs could be developed to work against.
Grant award
£130,220
Duration
2011 - 2013
Institution
Beatson Institute, University of Glasgow
Project title
How do the molecules Sprouty2 and PI3/AKT promote growth of prostate cancer?
Researcher
Professor Hing Leung
Summary
This project will use human prostate cancer samples to study the activity of the molecules Sprouty2 and PI3/AKT in prostate cancer. The aim is to develop targeted and individual treatment plans for men using these two molecules, by first of all understanding how they work together to cause the spread of aggressive prostate cancer, and their role as the cancer progresses and develops resistance to standard treatments.
Grant award
£150,812
Duration
2011 - 2014
Institution
University of Bradford
Project title
A new treatment for advanced prostate cancer with improved response and low side effects
Researcher
Dr Jason Gill
Summary
The project plan is to develop a new chemotherapy for prostate cancer which will act directly against the tumour with significantly reduced side effects, and have specific activity against advanced prostate cancer.
Grant award
£257,816
Duration
2011 - 2014
Institution
University of Cambridge
Project title
A new strategy to stop growth factors in advanced prostate cancer
Researcher
Dr Satoshi Hori
Summary
This project will test if increasing levels of a gene called Sef in prostate cancer cells can improve the efficacy of current treatments and prevent prostate cancer progression. The ultimate aim is to develop a new way of treating advanced prostate cancer by blocking its growth.
Grant award
£64,661
Duration
2011 - 2013
Institution
University of Cambridge
Project title
The role of cell regulation processes in the growth, progression and treatment resistance of prostate cancer.
Researcher
Professor David Neal
Summary
This project focuses on the role played by a mechanism called ‘autophagy’ in prostate cancer cells, and will investigate whether altering this process could be used to treat the cancer. Autophagy is a process that tightly regulates cell growth by enabling death of older cells, the degradation of their components, and recycling of cellular products for the growth of new cells. This process is thought to be lost in the early stages of cancer thus allowing rapid, uncontrolled growth of cancer cells; however, it may be reactivated in larger tumours, causing tumour cells to spread to other parts of the body, and perhaps helping the tumour to resist drug treatments.
Grant award
£43,851
Duration
2011 - 2013
Institution
University of Bradford
Project title
A new treatment for advanced prostate cancer
Researcher
Dr Helen Sheldrake
Summary
This is a pilot award to develop a treatment which blocks specific cell surface molecules called the Beta-3 integrins, which are involved in help allowing prostate cancer to survive, grow, and spread through the blood stream and into the bones. Currently this advanced type of prostate cancer cannot be controlled by existing treatments once it has spread to the bones.
Grant award
£49,992
Duration
2011 - 2012
Institution
Imperial College London
Project title
Studying the role the GNMT protein plays in prostate cancer
Researcher
Dr Lakjaya Buluwela
Grant award
£102,220
Duration
2008 - 2011
Institution
Institute of Cancer Research
Project title
Developing a way to predict the aggressiveness of prostate cancer.
Researcher
Professor Colin Cooper
Grant award
£152,475
Duration
2008 - 2011
Institution
Royal Marsden Hospital
Project title
A new method to improve the delivery of dose escalated prostate radiotherapy
Researcher
Ms Ashley d'Aquino
Grant award
£198,916
Duration
2014 - 2017
Institution
University College London
Project title
New ultrasound images to find aggressive prostate cancer
Researcher
Mr Hashim Ahmed
Grant award
£171,677
Duration
2014 - 2016