Developing a way to predict the aggressiveness of prostate cancer.

Institute of Cancer ResearchProfessor Colin Cooper£152,4752008 - 2011

Why we funded it

The forms and aggressiveness of prostate cancer vary greatly. New ways of predicting how a man's prostate cancer will develop are needed in order to help men with prostate cancer decide which treatment option to choose. Professor Cooper is looking to see if two genetic markers can provide such a prediction. He will be using large collaborative networks increasing the project's value for money and chance of success. The project will also further the understanding of how prostate cancer works and provide a basis for further research into new diagnostic and therapeutic interventions.

Scientific title: A mechanism-based system of classification for human prostate cancer.

Research project summary

Professor Cooper will investigate whether two newly identified genetic markers can help clinicians manage prostate cancer. In some prostate cancers the PTEN gene is deleted and/or the ERG gene is mutated. The project aims to find out if the presence or absence of these genes can predict how aggressive a man's prostate cancer will be and how it will respond to different treatments. This will be a large study using samples from over 1200 different prostate tumours. The project will also uncover molecular details about how the genetic mutations influence the progression of the disease.