Why We Funded It:
This study will investigate why men with prostate cancer stop
responding to treatment. When men stop responding to treatment
their prostate cancer progresses quickly and their survival period
is reduced to an average of 24 months. By understanding why
this happens, we might be able to prevent/delay it.
Scientific Title: The role of IKKa and IKKb in
prostate cancer progression.
Research project summary:
The research team plan to use to use prostate cancer specimens
taken from men before treatment and after the men no longer respond
to treatment to investigate what changes occur. Once
identified, these changes will be altered and/or manipulated to see
if this will stop the cancer from further growing. More
specifically, the team are interested in a group of molecules in an
inflammatory pathway, known as NFkB, IKKa and IKKb. This is a very
well characterised inflammation pathway which is thought to be
involved in prostate cancer becoming resistant to hormone
treatments. Inflammatory pathways are also under investigation in
other studies as potential driving factors behind the development
of prostate cancer. If successful this project could provide
alternative ways of treating prostate cancer.
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