The project in a nutshell
Working out why blocking an enzyme called LSD1 stops the growth
of prostate cancer cells.
Why we funded it
Hormonal therapies deplete or block the effects
of hormones such as testosterone which stimulate androgen receptors
on prostate cancer cells. Androgen receptors are critical in
causing prostate cancer cells to grow.
LSD1 is known to contribute to 'activation' of
androgen receptors and previous research shows that drugs which
stopped LSD1 from working also stopped prostate cancer cells
growing. This research project will look to determine why this
happens, and could lead to an entirely new approach to treating
For more detailed information on this project,
please look at the lay summary