In a nutshell
This project will look at expression of aldehyde dehydrogenase
enzymes to find out how these enzymes are involved in the
development of aggressive prostate cancer, and whether there is the
potential to use any of these markers for the diagnosis of
Why we funded it
Advanced prostate cancer that no longer responds to hormone
therapy is very difficult to treat, so we need to develop new
treatment options. This project focuses on a set of enzymes called
aldehyde dehydrogenases (ALDHs). Research suggests that there is a
link between high levels of ALDH enzymes and cancer growth and
spread (metastasis), but we don't know much yet about the
underlying biology of this link. We hope that studying ALDHs and
cancer growth will increase our understanding of the latter, so we
will eventually be able to prevent it from happening.
Read a more detailed summary of this project here.