In a nutshell
This project will study a group of proteins called adhesion
molecules in the stromal cells (non-cancerous supporting cells)
around a tumour. Scientists think that changes in these
molecules allow cancer cells to escape from the primary tumour and
spread (metastasise). Testing how drugs against these
molecules in mixed prostate cancer/stromal cell cultures affect
cancer cell spread may be the first step in developing a new drug
to prevent metastasis.
Why we funded it
Prostate cancer that has spread to another part of the body
(metastasised) is currently very difficult to treat. The ability to
prevent this occurring would represent a big step forward in our
ability to treat prostate cancer. Previous research has shown that
changes occur in the tumour itself and also in the cells
surrounding and supporting it when the cancer spreads. These
non-cancerous supporting cells are called stromal cells and are the
focus of this project. The scientists hope that this work will
provide valuable insights into how cancer cells migrate (move) and
spread, and therefore how to prevent it.
Read a more detailed summary of this project here.